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Equity · Healthcare

SYRE

NASDAQ

Spyre Therapeutics, Inc.

$100 +6.38% vs prior close Finazon · prior-day close, indicative (IEX-derived, not the official close)
Price · Chart

This price chart is drawn by TradingView, from their own data, in an embed loaded from their servers. We hold too few licensed daily closes of our own for SYRE to draw a line in its place.

Track this symbol on TradingView TradingView chart
Market cap $8.8B
52-week range $15 – $102
Avg volume 393.0K

as of Jul 17, 2026

SYRE insider trades

SEC Form 4 · last 90 days · newest reported trade 1 Oct 2026
Open-market buys 0
Open-market sells 12
Net sold $16.90M
Non-trade filings 8
Date Insider Type Shares Value
01 Oct 2026 Burrows Scott L Chief Financial Officer Sell 7,500 $689K
01 Oct 2026 King-Jones Heidy See Remarks Sell 28,933 $2.63M
01 Oct 2026 Turtle Cameron Chief Executive Officer Sell 15,000 $1.38M
30 Sep 2026 Burrows Scott L Chief Financial Officer Sell 17,500 $1.57M
02 Sep 2026 Burrows Scott L Chief Financial Officer Sell 18,232 $1.63M
02 Sep 2026 King-Jones Heidy See Remarks Sell 400 $36K
01 Sep 2026 Burrows Scott L Chief Financial Officer Sell 7,500 $655K
01 Sep 2026 King-Jones Heidy See Remarks Sell 27,999 $2.44M
01 Sep 2026 Turtle Cameron Chief Executive Officer Sell 15,000 $1.31M
07 Aug 2026 Albers Jeffrey W. Director Sell 23,000 $2.40M
03 Aug 2026 Burrows Scott L Chief Financial Officer Sell 7,500 $717K
03 Aug 2026 Turtle Cameron Chief Executive Officer Sell 15,000 $1.43M

Compensation mechanics Share grants, option exercises, tax withholding and transfers. They reach the same Form 4 as a trade, but they are not the insider buying or selling on the open market, so no purchase or sale value applies to them.

Date Insider Type Shares Value
01 Oct 2026 Burrows Scott L Chief Financial Officer Option exercise 7,500 $109K
01 Oct 2026 King-Jones Heidy See Remarks Option exercise 28,933 $420K
30 Sep 2026 Burrows Scott L Chief Financial Officer Option exercise 17,500 $254K
02 Sep 2026 King-Jones Heidy See Remarks Option exercise 400 $6K
01 Sep 2026 Burrows Scott L Chief Financial Officer Option exercise 7,500 $109K
01 Sep 2026 King-Jones Heidy See Remarks Option exercise 27,999 $406K
07 Aug 2026 Albers Jeffrey W. Director Option exercise 5,000 $52K
03 Aug 2026 Burrows Scott L Chief Financial Officer Option exercise 7,500 $109K

SYRE reported financials

SEC EDGAR XBRL SEC EDGAR

SYRE reported revenue of $0 for the fiscal year ended 31 Dec 2025. Net income over the same period was −$155.2M.

Figure Reported Period
Revenue $0 31 Dec 2025 fiscal year
Net income −$155.2M 31 Dec 2025 fiscal year
Total assets $1.2B 30 Jun 2026 at period end
Total equity $1.1B 30 Jun 2026 at period end

SYRE earnings

SEC EDGAR
Date Period EPS Revenue
30 Jun 2026 Q2 2026 −$1.09 —
31 Mar 2026 Q1 2026 −$0.74 —
31 Dec 2025 FY 2025 — —
30 Sep 2025 Q3 2025 −$1.24 —
30 Jun 2025 Q2 2025 −$1.09 —
31 Dec 2024 FY 2024 — —
30 Sep 2024 Q3 2024 $1.06 —
30 Jun 2024 Q2 2024 $0.59 —

Next report no date announced in SEC filings yet

Reported figures & scheduled dates · SEC EDGAR filings

SYRE institutional holders

SEC Form 13F SEC EDGAR

9 of the 45 institutional funds we track reported a SYRE position for the quarter ended 30 Jun 2026 — a combined $134.2M; the latest of those filings landed 02 Sep 2026.

Fund Action Shares Value
Marshall Wace Added +612.1% shares 991,693 $88.0M
Millennium Management Added +34.1% shares 196,712 $17.5M
Balyasny Asset Management Added +165.1% shares 147,042 $13.1M
Citadel Advisors Held (±25%) −4.7% shares 103,100 $9.2M
D. E. Shaw & Co. New position 26,452 $2.3M
AQR Capital Management Held (±25%) +9.9% shares 22,937 $2.0M
Two Sigma Investments New position 12,771 $1.1M
Man Group Held (±25%) −19.2% shares 7,714 $685K
Tudor Investment Corp Trimmed −68.4% shares 2,645 $235K
Baker Bros. Advisors Exited

SYRE fails-to-deliver

SEC CNS data SEC

On 24 Sep 2026, 788 shares of SYRE failed to deliver (about $69K).

Settlement date Shares failed Notional % of shares out
24 Sep 2026 788 $69K 0.001%
21 Sep 2026 5,660 $511K 0.006%
18 Sep 2026 27 $3K <0.001%
14 Sep 2026 9 $815 <0.001%
10 Sep 2026 24,790 $2.2M 0.028%

Sources

  1. Finazonprior-day close, indicative (IEX-derived, not the official close)
  2. TradingViewthe price chart widget, drawn by TradingView from their own data
  3. SEC EDGARSEC EDGAR XBRL company facts · latest period ended 30 Jun 2026
  4. SEC EDGARSEC EDGAR 13F filings
  5. SECSEC fails-to-deliver (CNS) data
  6. SEC EDGARValuation computed from SEC EDGAR filings